In a large non-stick skillet over medium heat sauté the onion, parsley, jalapeno, red bell pepper and celery (if using). Remove from heat and let cool
While the onion mixture is cooling, combine the chopped fresh salmon, ¼ cup Panko, 2 tablespoons of Mayonnaise, 1 teaspoon Dijon, Dash of Siracha and Worcestershire, the egg and lemon juice. Gently combine and add the cooled onion mixture.
Place the remaining Panko in a shallow bowl or plate.
Using a ¼-cup portioner or spoon, scoop salmon mixture into your hand and flatten and shape into a 2½-inch wide patty. Carefully place in the panko and coat both sides, gently patting the panko into the salmon mixture. Remove and repeat with the remainder of the salmon mixture.
Heat the large non-stick skillet over medium-high heat. Add 4 salmon cakes and cook until golden brown. Using a spatula, carefully turn the patties over and continuing to cook for another 5-6 minutes and the second side is golden brown and the salmon is fully cooked.